Detalhe da pesquisa
1.
Synthesis of diastereomerically pure nucleotide phosphoramidates.
J Org Chem
; 76(20): 8311-9, 2011 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21916475
2.
Stereoselective synthesis of PSI-352938: a ß-D-2'-deoxy-2'-α-fluoro-2'-ß-C-methyl-3',5'-cyclic phosphate nucleotide prodrug for the treatment of HCV.
J Org Chem
; 76(10): 3782-90, 2011 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21469736
3.
Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
Bioorg Med Chem Lett
; 20(15): 4539-43, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20580554
4.
2'-deoxy-2'-α-fluoro-2'-ß-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.
Bioorg Med Chem Lett
; 20(24): 7376-80, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21050754
5.
An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.
J Org Chem
; 74(17): 6819-24, 2009 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19642660
6.
Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential.
Nat Med
; 24(9): 1407-1417, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30082863
7.
The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo.
Sci Signal
; 10(467)2017 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28223414
8.
Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.
J Med Chem
; 48(20): 6454-60, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190771
9.
Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics.
Curr Med Chem
; 11(6): 775-93, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15032731
10.
Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture.
Antivir Chem Chemother
; 15(1): 43-55, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15074714
11.
N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.
Antivir Chem Chemother
; 14(2): 81-90, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12856919
12.
Phosphoramidate prodrugs of (-)-ß-D-(2R,4R)-dioxolane-thymine (DOT) as potent anti-HIV agents.
Antivir Chem Chemother
; 22(5): 217-38, 2012 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22358223
13.
Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.
ACS Med Chem Lett
; 2(2): 130-5, 2011 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900291
14.
Discovery of a ß-d-2'-deoxy-2'-α-fluoro-2'-ß-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.
J Med Chem
; 53(19): 7202-18, 2010 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20845908
15.
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.
Antimicrob Agents Chemother
; 47(1): 244-54, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12499198